- Advertisement for Madame Togno's School for Young Ladies, ca. 18551
- Agatha Aimar Simmons Papers, 1903-19621
- Agricultural Experiments and South Mulberry Plantation Journal, 1841-1907 (bulk 1841-1867)1
- Berkeley County (S.C) Memories1
- Bowman Family Papers, 1835-18921
- Buildings and Properties, 1841-19371
- Chesnut Family Papers, 1741-19001
- Cleveland L. Sellers, Jr. Papers, 1934 - 20031
- Collected Civil War Papers of Colonel Benjamin Franklin Eshleman1
- Collected Receipts of William Butler of Greenville1
- Congarees Store Account Book1
- Cora Godfrey Justice Family Papers, 1816-19871
- Cote Bas and Mepkin Plantations Journals, 1865-18771
- Dirleton Plantation Memorandum Book, 1859-19281
- Esau Jenkins Papers, 1963-20031
- George Chicken Journal, 1715-17161
- Good Hope Plantation Journal, 1835-1874 (bulk 1835-1857)1
- Halley's Comet Project, 1985-19861
- Holloway Family Collection1
- Isaiah Bennett Papers, ca. 1932-20021