- Historical and Governing Records, 1841-19253
- John P. Berry Papers, 1844-18973
- Rose Hill Plantation Time Books, 18783
- The Marian Bruce Logan Collection of Civil Rights Activism, Personal Correspondence, 1945-19893
- Thomas J. Tobias papers, ca. 1790-19703
- Waring Manuscript3
- William ("Bill") Saunders Papers, circa 1950 - 20043
- Charleston Branch of the National Association for the Advancement of Colored People Papers, 1920-19952
- Collection of Bishop Patrick Lynch Confederate Commissioner Papers, 1864-18652
- Erastus W. Everson Papers, 1837-18932
- Esau Jenkins Papers, 1963-20032
- Francis Peyre Porcher Papers2
- Historic Southern Naturalists2
- Isaac Harby Family Papers2
- John McCray Papers, 1932-19602
- Modjeska Simkins Papers, 1909-19922
- Paul Hamilton Papers2
- Septima P. Clark Papers, ca. 1910-ca. 19902
- William Tennent III Journal and Album2
- YWCA of Greater Charleston, Inc., Records, 1906 - 20072