- Diary and Account Book of Rene Ravenel and Henry Ravenel, 1731-186032
- Diary of Charles Drayton I, 1791-179820
- Dirleton Plantation Memorandum Book, 1859-19281
- Drayton Family Papers, 1837-186965
- Drayton Papers, 1701-20047
- Drayton family papers, 1837-18691
- Edmondston-Alston Family Letters and Paper Materials, 1782-19191,233
- Edwin Hughes Collection371
- Eighteenth & Nineteenth Century Correspondence Collection4
- Eleanor Phelps World Cruise Scrapbook2
- Eliza Pinckney Receipt Book1
- Elizabeth W. Allston Pringle Family Papers, 1861-19262
- Ellinor P. Gadsden Family Papers, 1848-19701
- Emily Clarkson Ball Grainger Family Papers, 1839-1962 (bulk 1926-1950)2
- Erastus W. Everson Papers, 1837-189317
- Esau Jenkins Papers, 1963-20038
- Ethelyn Murray Parker Papers3
- Eugene Avery Adams papers, 1892-196897
- Eugene C. Hunt Papers, 1834 - 199425
- Extract from the minutes of the monthly meeting, 1887 - Mechanics' Union No. 11