- James N. Cochran Papers, 1838-18871
- John Henry McCray papers, 1929-19891
- John P. Berry Papers, 1844-18971
- John West: In His Own Words1
- Journal of Robert Barnwell Plantations, 1838-18591
- Lazarus and Hirsch Family Papers1
- Loose Papers of the Summerville Museum and Research Center1
- Lucas-Porcher Family Papers, 1827-19721
- Malloy Family Papers, 1861-19071
- Manigault Family Papers, 1685-19711
- Mary Motte Alston Pringle Receipt Book1
- McLeod Family Papers, 1873-1990 (bulk 1900-1965)1
- Mills Family of Greenville1
- Modjeska Simkins Papers, 1909-19921
- Neves Family Letters1
- Pinckney-Means Family Papers, 1701-19831
- The James Poyas Daybook1
- Waring Manuscript1
- Wilkinson-Keith Family Papers1
- William Henry Johnson Scrapbook1