- 2nd South Carolina Regiment Order Book and Related Records, 1777-ca. 19291
- Account Books of Benjamin Perry's Wards, 1841-18641
- Bonds Conway Papers, 1763-19071
- Bowman Family Papers, 1835-18921
- Certificate of citizenship, 1871 - McCormick, John, fl. 18711
- Charles Fraser Book of Precedents, 1800-18191
- Charleston City Directories1
- Chesnut Family Papers, 1741-19001
- City Year Books for Charleston, South Carolina, 1880-19511
- Collected Civil War Papers of Colonel Benjamin Franklin Eshleman1
- Collected Receipts of William Butler of Greenville1
- Cote Bas and Mepkin Plantations Journals, 1865-18771
- Craft and Crum Families, 1780-20071
- DeBerniere Family Papers, 1790-1930 (bulk 1790-1860)1
- Deas Family Papers and Research, 1766-19761
- Emily Clarkson Ball Grainger Family Papers, 1839-1962 (bulk 1926-1950)1
- Eugene C. Hunt Papers, 1834 - 19941
- Good Hope Plantation Journal, 1835-1874 (bulk 1835-1857)1
- James Simons Papers, 1832-18791
- James W. Colbert, Jr., MD, Oral History Project, 20091