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Collection
- Chesnut Family Papers, 1741-19001
- Civic Services Committee Papers133
- Collected Papers of the Holland Family of Greenville County1
- Cote Bas and Mepkin Plantations Journals, 1865-18771
- Eighteenth & Nineteenth Century Correspondence Collection1
- Family Bible Records1
- Flagg Family Papers, 1832-19261
- Fraser Family Papers, 1755-18721
- Frederick E. Kredel, M.D. Papers, 1925-19804
- Gertrude Sanford Legendre Papers, 1844-19961
- Grimke family papers, 1678-19778
- Halley's Comet Project, 1985-19862
- Historic Southern Naturalists1
- Horace Gilbert Smithy, Jr., M.D. Papers3
- James Glen Papers3
- Journal of Robert Barnwell Plantations, 1838-18591
- Langdon Cheves Papers, 1777-18641
- Malloy Family Papers, 1861-19072
- Mamie E. Garvin Fields Papers, 1894 - 19871
- Slave Records in the Discrete Manuscript Collection3