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Collection
- Agatha Aimar Simmons Papers, 1903-19621
- American Revolution Records in the Discrete Manuscript Collection1
- Anna E. Alston Albums, 1880-19211
- Anne Simons Deas papers, ca. 1900.1
- Ball Family Papers, 1631-189595
- Ball Family Papers, 1631-18962
- Barnwell Family Papers3
- Charleston Museum Collection of Revolutionary War Letters1
- Circular Congregational Church Records, 1732-1796 (bulk 1800-1910s)4
- Civic Services Committee Papers85
- Clemson University Class of 19391
- Coffin Point Plantation Journals, 1800-18165
- Colin J. McRae Papers, Huse Audit Series1
- Continental Army Southern Department Records, 1778-1890 (Bulk 1778-1780)4
- Drayton Family Papers, 1837-18692
- Edmondston-Alston Family Letters and Paper Materials, 1782-19195
- Edwin Hughes Collection2
- Flagg Family Papers, 1832-19262
- Francis Peyre Porcher Papers2
- Gabriel Manigault Journal, 1774-17841