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Collection
- Horace Gilbert Smithy, Jr., M.D. Papers33
- Letters to Alfred Wardlaw, 1857-186211
- The Joel Myerson Collection of Nineteenth-Century American Manuscripts, Images, and Ephemera6
- St. Paul's Episcopal Church records, 1819-19713
- University of South Carolina Student Exams, 1854 - 19172
- Waring Historical Library Inaugural Theses2
- Allston Family Papers, 1730-19011
- Edwin Hughes Collection1
- Gooch Family Papers, 1754-19471
- Grimke family papers, 1678-19771
- John Ravenel Estate Book, 1862-18701
- Langdon Cheves Papers, 1777-18641
- MUSC College of Dental Medicine Oral History Project, 20111
- Manigault Family Papers, 1685-19711
- Slave Records in the Discrete Manuscript Collection1
- South Carolina Historical Records Survey Collection1
- South Carolina and the Civil War1
- Strom Thurmond Collection, Mss 1001
- Thomas J. Tobias papers, ca. 1790-19701
- Walter Pantovic Slavery and African American History Collection1