- Goldberg Family Papers, 1902-19532
- Grimke family papers, 1678-197761
- Halley's Comet Project, 1985-19861
- Harby Academy Cashbook1
- Hebrew Benevolent Society Papers1
- Henry Laurens Account Book, 1766-17331
- Heyward and Ferguson Family Papers, 1806-1923389
- Illustrated Newspaper Clippings, 1840-191728
- Irish Heritage Oral History Collection13
- Irish Volunteers Company records, 1798-19292
- Isaac Harby Family Papers6
- J. F. R. Papers, 1849-18551
- Jewish Heritage Collection Oral Histories135
- Jewish Heritage Collection Personal Papers1
- Kahal Kadosh Beth Elohim Congregation Records38
- L. Mendel Rivers Papers, 1940-19628
- Lazarus and Hirsch Family Papers10
- Leah Greenberg Postcard Collection209
- Lewis R. Gibbes Papers, 1800s-1893, 193710
- Lowcountry Tourism5