- Dientje Krant Kalisky Adkins Photographs, 1938-199622
- College of Charleston Publications21
- Roy S. MacElwee Collection21
- Francine Ajzensztark Taylor Papers, circa 1913-198517
- Alliance for Full Acceptance records16
- Senator Burnet R. Maybank Papers, 1914-197314
- Irish Heritage Oral History Collection13
- South Carolina Inter-State and West Indian Exposition, 1901-190212
- William M. Halsey and Corrie McCallum Paintings12
- Lazarus and Hirsch Family Papers10
- Lewis R. Gibbes Papers, 1800s-1893, 193710
- B. A. Rodrigues Ottolengui Collection9
- William Martin Aiken Papers, 1878-19569
- College of Charleston Pamphlet Collection8
- L. Mendel Rivers Papers, 1940-19628
- Reverend Alexander Glennie Meteorological Observations, 1834-18808
- Isaac Harby Family Papers6
- Zionist Organization of America Records6
- Lowcountry Tourism5
- Warren Hubert Moise Letters, 1933-19395