- Nathaniel Russell Middleton Papers, 1823-18814
- No problems, only challenges : the autobiography of Theodore S. Stern1
- Phillips Family Papers4
- Pierrine Smith Byrd Papers, 1919-1991135
- Rabbi Jacob S. Raisin Papers87
- Reverend Alexander Glennie Meteorological Observations, 1834-18808
- Roswell T. Logan Journal, 1852-18651
- Roy S. MacElwee Collection21
- Samuel Lord Hyde Photographs27
- Senator Burnet R. Maybank Papers, 1914-197314
- South Carolina Inter-State and West Indian Exposition, 1901-190212
- South Carolina LGBTQ Oral Histories, Archives, and Outreach51
- St. Andrew's Society of Charleston Records, 1729-2001117
- Temple Sinai (Sumter, S.C.) Records106
- The Black Whale, by Gabriel E. Manigault1
- The Joseph Mordecai Hirschmann Collection197
- Thomas J. Tobias papers, ca. 1790-197029
- Warren Hubert Moise Letters, 1933-19395
- Wilkinson-Keith Family Papers242
- William A. Rosenthall Judaica Collection - Postcards1