- Thomas J. Tobias papers, ca. 1790-197029
- Dientje Krant Kalisky Adkins Photographs, 1938-199622
- College of Charleston Publications21
- Roy S. MacElwee Collection21
- Irish Heritage Oral History Collection19
- L. Mendel Rivers Papers, 1940-196218
- Francine Ajzensztark Taylor Papers, circa 1913-198517
- Alliance for Full Acceptance records16
- South Carolina Inter-State and West Indian Exposition, 1901-190212
- William M. Halsey and Corrie McCallum Paintings12
- Lazarus and Hirsch Family Papers10
- Lewis R. Gibbes Papers, 1800s-1893, 193710
- B. A. Rodrigues Ottolengui Collection9
- William Martin Aiken Papers, 1878-19569
- College of Charleston Pamphlet Collection8
- Reverend Alexander Glennie Meteorological Observations, 1834-18808
- Warren Hubert Moise Letters, 1933-19397
- William A. Rosenthall Judaica Collection - Postcards7
- College of Charleston Stereoscope Views6
- Gertrude Sanford Legendre Papers, 1844-19966