- Joseph A. DeLaine Papers10
- Joseph E. Winter Photograph Collection4,087
- Kenneth Frederick Marsh Photograph Collection11
- Keziah Brevard Journal, 1860-18611
- M. Hayes Mizell Papers108
- Maxcy Gregg Papers, 1835-1888.2
- Minutes of the Annual Conferences of the Baptist, Episcopal, Lutheran, Methodist, and Presbyterian Churches in South Carolina, 1785-192037
- Paul Hamilton Papers2
- Primary Sources for K-12, Pilot Project5
- Proclamations, Politics, and Commerce: Broadsides from the Colonial Era to the Present at the South Caroliniana Library155
- Program of... the Bishop's Council of the African Methodist Episcopal Church1
- Sanborn Fire Insurance Maps of South Carolina11
- Smith and Wells Papers, 1856-19076
- South Carolina Fall Line Collection12
- South Carolina Historical Records Survey Collection150
- South Carolina Postcards1
- South Carolina Railroad Photograph Collection20
- South Carolina and World War II57
- South Carolina and the Civil War50
- South Carolina and the Spanish American War15