- Berkeley County Photograph Collection5
- Henry William Ravenel Papers, 1739-19354
- Joseph A. DeLaine Papers4
- Lanny and Sidney Palmer Collection4
- John Hensel Photograph Collection3
- John Shaw Billings Scrapbook3
- Joseph E. Winter Photograph Collection3
- Lutheran Church Records of South Carolina3
- South Carolina and the Spanish American War3
- Tom Crosby oral history collection, 2006-20113
- WPA Federal Writers' Project on African American Life in South Carolina3
- Chester County Historical Collection, 1739-19972
- Thomas Family Collection 2
- University of South Carolina Reconstruction Records1
- Armstrong Family Papers, 1900-19301
- David Wyatt Aiken Papers, 1849-19761
- George LaGrange Cook Photograph Collection1
- Minutes of the Annual Conferences of the Baptist, Episcopal, Lutheran, Methodist, and Presbyterian Churches in South Carolina, 1785-19201
- Phosphates in South Carolina, 1870-18901
- South Caroliniana Library Oral History Collection1