- Dirleton Plantation Memorandum Book, 1859-19281
- Drayton family papers, 1837-18691
- Early California Scrapbooks1
- Eliza Pinckney Receipt Book1
- Ellinor P. Gadsden Family Papers, 1848-19701
- Extract from the minutes of the monthly meeting, 1887 - Mechanics' Union No. 11
- Frank Fisher Notes, 1882-19021
- Fraser Family Papers, 1755-18721
- Gaillard Family Papers, 1758-19011
- Gaillard Family Papers, 1795-18501
- General Orders of William Moultrie and Benjamin Lincoln, 17791
- George Chicken Journal, 1715-17161
- Glendia Cooper Collection1
- Glenn Drayton journal, 1814-18641
- Glimpses of the South Carolina Interstate and West Indian Exposition1
- Golf1
- Good Hope Plantation Journal, 1835-1874 (bulk 1835-1857)1
- Gourdin Family Collection, 1707-19031
- Greenville High School Yearbooks1
- Greenvillle Health System1