- The State Newspaper Photograph Archive9
- Butler Derrick: In His Own Words8
- South Carolina Aerial Photograph Indexes, 1937-19898
- South Carolina Fall Line Collection8
- Proclamations, Politics, and Commerce: Broadsides from the Colonial Era to the Present at the South Caroliniana Library7
- Continental Army Southern Department Records, 1778-1890 (Bulk 1778-1780)6
- Cooperative Annual Reports6
- South Caroliniana Library Map Collection6
- Topographical Maps of South Carolina, 1888 -19756
- Jewish Heritage Collection Oral Histories5
- Kenneth Frederick Marsh Photograph Collection5
- Minutes of the Annual Conferences of the Baptist, Episcopal, Lutheran, Methodist, and Presbyterian Churches in South Carolina, 1785-19205
- Charleston Earthquake 18864
- South Carolina Baptist Church Records4
- Joseph E. Winter Photograph Collection3
- South Carolina and the Civil War3
- WPA Federal Writers' Project on African American Life in South Carolina3
- David Wyatt Aiken Papers, 1849-19762
- Eleanor Phelps World Cruise Scrapbook2
- M. Hayes Mizell Papers2