- Mamie E. Garvin Fields Papers, 1894 - 19872
- Mary Motte Alston Pringle Receipt Book2
- Minutes of the Annual Conferences of the Baptist, Episcopal, Lutheran, Methodist, and Presbyterian Churches in South Carolina, 1785-19202
- Pringle-Garden Family Papers, 1701-18822
- Richard Furman and James C. Furman Collection2
- South Carolina Library Buildings Collection2
- Armstrong Family Papers, 1900-19301
- Atlas of the state of South Carolina by Robert Mills1
- Ball Family Papers, 1631-18951
- Beulah Glover Photograph Collection1
- Charleston Museum Plantation Photographs1
- Coffin Point Plantation Journals, 1800-18161
- Diaries1
- Edmondston-Alston Family Letters and Paper Materials, 1782-19191
- Elizabeth Pringle Diaries1
- Ethelyn Murray Parker Papers1
- Fritz Hollings: In His Own Words1
- Grimke family papers, 1678-19771
- Henry Laurens papers, 1747-18601
- Housworth Stereographs Collection1