- Gaillard Family Papers, 1758-19011
- George LaGrange Cook Photograph Collection1
- Gertrude Sanford Legendre Papers, 1844-19965
- Henry William Ravenel Papers, 1739-193570
- Henry William Ravenel's Private Journals1
- Home Movies from Moving Image Research Collections3
- Housworth Stereographs Collection1
- Hurricane Hugo Elevation Maps1
- Isabella Sarah Porcher Plantation Prescription Book1
- Jack Keilen Slide Collection55
- James T. McCain Papers, 1957-19722
- Jimmy Cornelius Stone Collection147
- John McCrady Plats and Deeds Collection16
- L. Mendel Rivers Papers, 1940-19621
- Leah Greenberg Postcard Collection6
- Letters to Jonathan Lucas, 17962
- Lucas-Porcher Family Papers, 1827-197212
- Lydia Jane Waring Estate Book, 1840-18471
- M. Hayes Mizell Papers20
- Materials towards a history of the Baptists in the provinces of Maryland, Virginia, North Carolina, South Carolina, Georgia1