- Newsletters and Pamphlets5
- No problems, only challenges : the autobiography of Theodore S. Stern1
- Oliver Hart papers, 1741-196142
- One Man's Dream - William Plumer Jacobs and Clinton, South Carolina3
- Parish Records2
- Paul Hamilton Papers12
- Personal Photographs of Sergeant Jesse Herring, Jr. during WWII, Fort Moultrie, South Carolina95
- Philip Simmons Collection63
- Phillips Family Papers4
- Phillis Wheatley Literary and Social Club Papers9
- Phosphates in South Carolina, 1870-189026
- Photograph Survey of the “Charleston Center” Site110
- Photographic Record of the Cooper River Bridge202
- Pierrine Smith Byrd Papers, 1919-1991135
- Pinckney Family Papers, 1703-18473
- Pinehurst Tea Plantation Visual Materials1
- Porcher Family Papers, 1740-1967 (bulk 19th century)1
- Postcards of the Midlands7
- Primary Sources for K-12, Pilot Project23
- Pringle-Garden Family Papers, 1701-18821