- Proclamations, Politics, and Commerce: Broadsides from the Colonial Era to the Present at the South Caroliniana Library228
- Quiver1
- Rabbi Jacob S. Raisin Papers87
- Records of Charleston fire companies, 1862-18647
- Records of the Bricklayers, Masons and Plasterers International Union of America, 1950-19558
- Register Mesne Conveyance Collections1
- Reverend Alexander Glennie Meteorological Observations, 1834-18808
- Richard Furman and James C. Furman Collection141
- Richland Library Archives1
- Robert Gilmor Travel Account1
- Robert Heriot Correspondence, 17811
- Robert McNair: In His Own Words1
- Roper Hospital Digital Collections1
- Roswell T. Logan Journal, 1852-18651
- Roy S. MacElwee Collection21
- Russell Maxey Photograph Collection24
- SCDOT Photographs: Properties in the Right-of-Way2,276
- Sabina E. Wells Photographs1
- Samuel Lord Hyde Photographs27
- Samuel Miller apprenticeship indenture, 18051