- Sanborn Fire Insurance Maps of South Carolina16
- Sanitary Survey of the Rural Portion of Charleston County, 19211
- Sarah Campbell Allan, M.D. Papers 1895-19526
- Sarah Campbell Allan, M.D. Papers 1895-19531
- Scenes in Charleston, Georgetown, and Flat Rock, Late 19th Century1
- Scenes in Charleston, ca. 1940s19
- Senator Burnet R. Maybank Papers, 1914-197314
- Septima P. Clark Papers, ca. 1910-ca. 1990290
- Shadows of the Gullah Geechee5
- Slave Records in the Discrete Manuscript Collection22
- Smith and Wells Papers, 1856-190721
- Somebody Had To Do It1
- South Carolina Aerial Photograph Indexes, 1937-19898
- South Carolina Artifact Documentation Project2
- South Carolina Baptist Church Records8
- South Carolina Bookmobiles Collection6
- South Carolina Dental Association Records2
- South Carolina Historical Society Manuscripts3
- South Carolina Historical Society Oral Histories11
- South Carolina Hospital Postcards10