- Drayton Papers, 1701-20041
- Emily Clarkson Ball Grainger Family Papers, 1839-1962 (bulk 1926-1950)1
- Grimke family papers, 1678-19774
- Helen Evangeline Banks Harrison papers (circa 1850 - 1985)3
- Henry William Ravenel Papers, 1739-19354
- Heyward and Ferguson Family Papers, 1806-192336
- Historic Charleston Foundation Oral History Project3
- Historical and Governing Records, 1841-19251
- Home Movies from USC's Moving Image Research Collections1
- Horace Gilbert Smithy, Jr., M.D. Papers5
- Images from the Records of the Charleston County Public Library1
- Isaiah DeQuincey Newman Papers4
- J. Marion Sims Letters2
- James Glen Papers5
- Jewish Heritage Collection Oral Histories6
- L. Mendel Rivers Papers, 1940-19622
- Langdon Cheves Papers, 1777-18641
- Laura Bragg Papers1
- Leah Greenberg Postcard Collection1
- Lewis R. Gibbes Papers, 1800s-1893, 19374