- South Carolina LGBTQ Oral Histories, Archives, and Outreach9
- Allston Family Papers, 1730-19018
- Agricultural Society of South Carolina Visual Materials6
- Grimke family papers, 1678-19776
- James Simons Papers, 1832-18796
- McLeod Family Papers, 1873-1990 (bulk 1900-1965)6
- Rabbi Jacob S. Raisin Papers6
- Thomas J. Tobias papers, ca. 1790-19706
- Lynch Family Letters, 1858-18665
- Proclamations, Politics, and Commerce: Broadsides from the Colonial Era to the Present at the South Caroliniana Library5
- Town of Sullivan's Island Historic Meeting Minutes5
- Barnwell Family Papers4
- Pierrine Smith Byrd Papers, 1919-19914
- SCDOT Photographs: Properties in the Right-of-Way4
- Catherine M. McCottry, M.D. Papers3
- Cranston Family Papers, 1822-19593
- Ethelyn Murray Parker Papers3
- MUSC College of Graduate Studies Class Photos3
- Transactions of the Huguenot Society of South Carolina3
- Burton L. Padoll Papers, 1957-20092