- MUSC College of Nursing Class Photos2
- McLeod Family Papers, 1873-1990 (bulk 1900-1965)2
- South Carolina LGBTQ Oral Histories, Archives, and Outreach2
- Allston Family Papers, 1730-19011
- Aqui Estamos1
- Bacot Family Papers, 1752-19731
- Ball Family Papers, 1631-18951
- C. Wayne Weart Apothecary Trade Cards, 1870-19201
- Charles Fraser's Sketchbook, 1796-18051
- Charleston Museum Earthquake Photographs1
- Civil War Newspaper Illustrations1
- College of Charleston Pamphlet Collection1
- Francine Ajzensztark Taylor Papers, circa 1913-19851
- Georgetown County Digital Library1
- Grimke family papers, 1678-19771
- Home Movies from Moving Image Research Collections1
- Images from the Records of the Charleston County Public Library1
- Irish Heritage Oral History Collection1
- L. Mendel Rivers Papers, 1940-19621
- Minutes of the Annual Conferences of the Baptist, Episcopal, Lutheran, Methodist, and Presbyterian Churches in South Carolina, 1785-19201