- Photographic Record of the Cooper River Bridge202
- The Charleston Oral History Program200
- The Joseph Mordecai Hirschmann Collection197
- The State Newspaper Photograph Archive184
- Medical University of South Carolina University Bulletins, 1878-2002182
- Images from the Records of the Charleston County Public Library181
- Continental Army Southern Department Records, 1778-1890 (Bulk 1778-1780)178
- South Caroliniana Library Map Collection158
- The South Carolina & West Indian Exposition Photo Passbook, 1901 - 1902157
- U.S. military in Fort Moultrie, South Carolina, 1900-1945157
- Charleston Earthquake 1886152
- Horace Gilbert Smithy, Jr., M.D. Papers152
- South Carolina State Parks Civilian Conservation Corps Architectural Plans143
- Richard Furman and James C. Furman Collection141
- Jewish Heritage Collection Oral Histories135
- Pierrine Smith Byrd Papers, 1919-1991135
- Southeast region sites129
- St. Andrew's Society of Charleston Records, 1729-2001117
- The South Carolina Artifact Documentation Project116
- Charles Fraser's Sketchbook, 1796-1805114