- Beulah Glover Photograph Collection5
- Black and white negatives of South Carolina State Parks, 1934-1967792
- Books and Pamphlets1
- Bowman Family Papers, 1835-18923
- Briggs v. Elliott4
- Buildings and Properties, 1841-193749
- Burton L. Padoll Papers, 1957-2009110
- Business Guide of Charleston, S.C.1
- Butler Derrick: In His Own Words2
- C. Wayne Weart Apothecary Trade Cards, 1870-1920251
- C. Wayne Weart Pharmacy History Collection37
- Carlton Simmons Collection2
- Catherine M. McCottry, M.D. Papers12
- Certificate of citizenship, 1871 - McCormick, John, fl. 18711
- Charles Fraser Book of Precedents, 1800-18191
- Charles Fraser's Sketchbook, 1796-1805114
- Charles N. Bayless Photos of Charleston and Georgetown County, S.C.1,401
- Charles Stuart Vedder Papers3
- Charleston Bible Society Records, 1815-20101
- Charleston City Directories4