- Business Guide of Charleston, S.C.1
- Butler Derrick: In His Own Words2
- C. Wayne Weart Apothecary Trade Cards, 1870-1920251
- C. Wayne Weart Pharmacy History Collection37
- Carlton Simmons Collection2
- Catherine M. McCottry, M.D. Papers12
- Certificate of citizenship, 1871 - McCormick, John, fl. 18711
- Charles Fraser Book of Precedents, 1800-18191
- Charles Fraser's Sketchbook, 1796-1805114
- Charles N. Bayless Photos of Charleston and Georgetown County, S.C.1,401
- Charles Stuart Vedder Papers3
- Charleston Bible Society Records, 1815-20101
- Charleston City Directories4
- Charleston City Records Collection1
- Charleston Dental Association Records30
- Charleston Earthquake 1886152
- Charleston Firefighters Rosters, 1862-186416
- Charleston Iron Works records, 19072
- Charleston Museum Collection1
- Charleston Museum Collection of Revolutionary War Letters70