- The South Carolina & West Indian Exposition Photo Passbook, 1901 - 1902157
- U.S. military in Fort Moultrie, South Carolina, 1900-1945157
- Charleston Earthquake 1886152
- Horace Gilbert Smithy, Jr., M.D. Papers152
- The State Newspaper Photograph Archive151
- South Carolina State Parks Civilian Conservation Corps Architectural Plans143
- Richard Furman and James C. Furman Collection141
- Jewish Heritage Collection Oral Histories135
- Pierrine Smith Byrd Papers, 1919-1991135
- Southeast region sites129
- St. Andrew's Society of Charleston Records, 1729-2001117
- The South Carolina Artifact Documentation Project116
- Charles Fraser's Sketchbook, 1796-1805114
- Burton L. Padoll Papers, 1957-2009110
- Photograph Survey of the “Charleston Center” Site110
- Temple Sinai (Sumter, S.C.) Records106
- MUSC College of Nursing Class Photos105
- James Glen Papers102
- George LaGrange Cook Photograph Collection99
- Agricultural Society of South Carolina Visual Materials98