- Clemson University Board of Trustees Minutes and Reports18
- Cleveland L. Sellers, Jr. Papers, 1934 - 200325
- Cloe T.W. Greene Diaries59
- College of Charleston Buildings and Grounds Photograph Collection1,059
- College of Charleston Magazines48
- College of Charleston Pamphlet Collection8
- College of Charleston Publications21
- College of Charleston Scrapbooks and Photo Albums2
- College of Charleston Stereoscope Views1
- Color Slides from Fort Sumter National Historical Monument2,290
- Color slides of South Carolina State Parks1,429
- Columbia Theater and Entertainment1
- Confederate Spartanburg1
- Conrad Wienges to James Drayton2
- Continental Army Southern Department Records, 1778-1890 (Bulk 1778-1780)178
- Cooperative Annual Reports6
- Cora Godfrey Justice Family Papers, 1816-19871
- Craft and Crum Families, 1780-200719
- Cranston Family Papers, 1822-195916
- Daily reports, 1863 Dec. 17-237