- David Wyatt Aiken Papers, 1849-19765
- Diaries80
- Diary of Charles Drayton I, 1791-179820
- Dientje Krant Kalisky Adkins Photographs, 1938-199622
- Drayton Family Papers, 1837-186946
- Drayton Papers, 1701-200431
- Drayton family papers, 1837-18691
- Edmondston-Alston Family Letters and Paper Materials, 1782-191982
- Edmondston-Alston Photograph Collection13
- Edwin A. Harleston Collection3
- Eighteenth & Nineteenth Century Correspondence Collection4
- Eliza Pinckney Receipt Book1
- Elizabeth Pringle Diaries21
- Emily Clarkson Ball Grainger Family Papers, 1839-1962 (bulk 1926-1950)2
- Equal Rights Amendment2
- Erastus W. Everson Papers, 1837-18931
- Esau Jenkins Papers, 1963-20035
- Ethelyn Murray Parker Papers35
- Extract from the minutes of the monthly meeting, 1887 - Mechanics' Union No. 11
- Fairfield County Manuscript Collection1