- John McCrady Plats and Deeds Collection1
- John West: In His Own Words5
- Kenneth Frederick Marsh Photograph Collection188
- M. Hayes Mizell Papers1
- McBee Sons & Company Store Ledger Book, 1846-1861508
- McLeod Family Papers, 1873-1990 (bulk 1900-1965)1
- Mercantile Agency Reference Book of South Carolina175
- Midlands Memories2
- Minutes of the Annual Conferences of the Baptist, Episcopal, Lutheran, Methodist, and Presbyterian Churches in South Carolina, 1785-192026
- Miscellaneous South Carolina Pamphlets1
- Newsletters and Pamphlets4
- Philip Simmons Collection1
- Phillis Wheatley Community Center27
- Piedmont Image Collection325
- Political Campaign Memorabilia Collection1
- Primary Sources for K-12, Pilot Project38
- Proclamations, Politics, and Commerce: Broadsides from the Colonial Era to the Present at the South Caroliniana Library11
- Richard Furman and James C. Furman Collection119
- Robert McNair: In His Own Words1
- Russell Maxey Photograph Collection2