- McBee Sons & Company Store Ledger Book, 1846-18611
- McLeod Family Papers, 1873-1990 (bulk 1900-1965)1
- Mercantile Agency Reference Book of South Carolina1
- Minutes of the Annual Conferences of the Baptist, Episcopal, Lutheran, Methodist, and Presbyterian Churches in South Carolina, 1785-192026
- Miscellaneous South Carolina Pamphlets1
- Newsletters and Pamphlets4
- Philip Simmons Collection1
- Piedmont Image Collection325
- Primary Sources for K-12, Pilot Project38
- Proclamations, Politics, and Commerce: Broadsides from the Colonial Era to the Present at the South Caroliniana Library11
- Richard Furman and James C. Furman Collection119
- Robert McNair: In His Own Words1
- Russell Maxey Photograph Collection2
- Sanborn Fire Insurance Maps of South Carolina17
- Semaphore62
- Senator Burnet R. Maybank Papers, 1914-19731
- Smith and Wells Papers, 1856-190734
- South Carolina Aerial Photograph Indexes, 1937-19898
- South Carolina Baptist Church Records6
- South Carolina Bookmobiles Collection13