- Kirkover Album1
- L. Mendel Rivers Papers, 1940-19621
- Midlands Memories2
- Minutes of the Annual Conferences of the Baptist, Episcopal, Lutheran, Methodist, and Presbyterian Churches in South Carolina, 1785-192013
- Papers of the Cox and Chesnut Families, 1792-1858212
- Pee Dee District Dental Society Records, 1933-19881
- Postcards of the Midlands14
- Proclamations, Politics, and Commerce: Broadsides from the Colonial Era to the Present at the South Caroliniana Library13
- Richard Furman and James C. Furman Collection10
- Robert Gilmor Travel Account1
- Russell Maxey Photograph Collection7
- Sanborn Fire Insurance Maps of South Carolina14
- South Carolina Aerial Photograph Indexes, 1937-19899
- South Carolina Baptist Church Records4
- South Carolina Bookmobiles Collection2
- South Carolina Department of Transportation County Road Maps14
- South Carolina Fall Line Collection1
- South Carolina Historical Records Survey Collection108
- South Carolina Hospital Postcards2
- South Carolina Library Buildings Collection5