- Cranston Family Papers, 1822-195910
- DeBerniere Family Papers, 1790-1930 (bulk 1790-1860)1
- Deas Family Papers and Research, 1766-19761
- Drayton Family Papers, 1837-18695
- Edmondston-Alston Family Letters and Paper Materials, 1782-1919722
- Eighteenth & Nineteenth Century Correspondence Collection2
- Ellinor P. Gadsden Family Papers, 1848-19701
- Flagg Family Papers, 1832-19262
- Fraser Family Papers, 1755-18721
- Furman's Legacy of Slavery1
- Gabriel Manigault Journal, 1774-17841
- Gaillard Family Papers, 1758-19011
- Gaillard Family Papers, 1795-18501
- Glover Family Papers, 1729-ca.19552
- Gooch Family Papers, 1754-194743
- Good Hope Plantation Journal, 1835-1874 (bulk 1835-1857)1
- Gourdin Family Collection, 1707-19031
- Henry Laurens papers, 1747-18601
- Huger Family Papers, 1795-18971
- Isaac Hayne Journal: Register, ca. 1764-17811