- Letter to Harriott Horry, ca. 17801
- Lucas-Porcher Family Papers, 1827-19721
- Macedonian Call4
- Manigault Family Papers, 1685-19711
- Mary Motte Alston Pringle Receipt Book1
- Middleton Papers, 1775-18154
- Mills Family of Greenville114
- Newsletters and Pamphlets4
- Pinckney Family Papers, 1703-18471
- Rabbi Jacob S. Raisin Papers8
- Ragsdale Family Papers, 1844-ca.19202
- Robert Heriot Correspondence, 17812
- Slave Records in the Discrete Manuscript Collection1
- South Carolina State Parks Signs, Brochures, and Manuals9
- Tarbox Family Photograph Collection2
- Thomas Benton Brooks Papers1
- Thomas J. Tobias papers, ca. 1790-19706
- Transactions of the Huguenot Society of South Carolina2
- William A. Rosenthall Judaica Collection - Postcards18
- William Moultrie Correspondence, 17812