- Home Movies from Moving Image Research Collections3
- John Henry McCray papers, 1929-19893
- Pawleys Island Civic Association3
- Williams, Chesnut, Manning Family Papers, 1682-19263
- Brookgreen Gardens Collection2
- Charleston Branch of the National Association for the Advancement of Colored People Papers, 1920-19952
- Family Bible Records2
- Greenville Current Campus (1958-present)2
- Henry Orion Nichols Collection2
- Lanny and Sidney Palmer Collection2
- MUSC College of Pharmacy Class Photos2
- St. Paul's Episcopal Church records, 1819-19712
- Ware Family Manuscripts2
- Bessie Norris Wofford collected funeral programs, 1957-19911
- Black and white negatives of South Carolina State Parks, 1934-19671
- C. Wayne Weart Pharmacy History Collection1
- Cleveland L. Sellers, Jr. Papers, 1934 - 20031
- Collected Papers of the Holland Family of Greenville County1
- Columbia Theater and Entertainment1
- Continental Army Southern Department Records, 1778-1890 (Bulk 1778-1780)1