- Ada Clare Papers, 1841-1864165
- Adger Family Papers, 1813-193211
- Advertisement for Madame Togno's School for Young Ladies, ca. 18551
- Aerial Photos of Columbia, Richland County, South Carolina (Pilot Project)1,986
- African American Social Clubs59
- After the Great Quake: Earthquake Views1
- Agatha Aimar Simmons Papers, 1903-19621
- Agricultural Experiments and South Mulberry Plantation Journal, 1841-1907 (bulk 1841-1867)1
- Agricultural Society of South Carolina Visual Materials211
- Alan Seeger, Le Poète de la Légion Étrangère1
- Albert Simons Papers, 1908-19774
- Albert Sottile, Jr. Papers250
- Ale boycott records, 18904
- Alexander Glennie Journal, 1831-18591
- Alexander Inglis Papers, 1782-1811 (bulk 1800-1802)2
- Alexander McBeth Store Ledger, 179494
- Alice Ravenel Huger Smith Collection2
- Allen University Digital Collections73
- Alliance for Full Acceptance records16
- Allston Family Papers, 1730-1901247