- Specimens from the Bob Campbell Geology Museum12
- Chibbaro Stereograph Collection: 186u-199711
- Henry Orion Nichols Collection11
- The Development of the Printed Page: 150 Examples of Handpress Printing and its Antecedents, ca. 1200 to 193711
- Home Movies from Moving Image Research Collections10
- At Low Tide Photographs9
- Greenville Current Campus (1958-present)9
- South Carolina and the Civil War9
- South Caroliniana Library Map Collection9
- John Henry Dick Collection8
- John Henry McCray papers, 1929-19898
- William D. Workman, Jr. Papers Photographs8
- Charleston Branch of the National Association for the Advancement of Colored People Papers, 1920-19957
- George LaGrange Cook Photograph Collection7
- Grimke family papers, 1678-19777
- McLeod Family Papers, 1873-1990 (bulk 1900-1965)7
- South Carolina LGBTQ Oral Histories, Archives, and Outreach7
- Cleveland L. Sellers, Jr. Papers, 1934 - 20036
- Harvey Gantt and the Integration of Clemson University6
- History of the University of South Carolina School of Medicine - Columbia6