- Strom Thurmond Collection, Mss 10024
- L. Mendel Rivers Papers, 1940-196222
- SCDOT Photographs: Properties in the Right-of-Way22
- The American Revolution in South Carolina22
- Pawleys Island Civic Association21
- William Lynch Postcard Collection19
- Ball Family Papers, 1631-189518
- Charleston Branch of the National Association for the Advancement of Colored People Papers, 1920-199518
- Slave Records in the Discrete Manuscript Collection18
- Butler Derrick: In His Own Words17
- Heyward and Ferguson Family Papers, 1806-192317
- Greenville Current Campus (1958-present)16
- Proclamations, Politics, and Commerce: Broadsides from the Colonial Era to the Present at the South Caroliniana Library16
- Senator Burnet R. Maybank Papers, 1914-197316
- Civic Services Committee Papers15
- Joseph E. Winter Photograph Collection15
- Lonnie W. Fleming, Sr. Photograph Collection15
- Grimke family papers, 1678-197714
- Russell Maxey Photograph Collection14
- William Drayton Rutherford Papers13