- Pages from the Past15
- The Charleston Oral History Program14
- United States Marine Corps Films14
- Colin J. McRae Papers, Huse Audit Series13
- John and Mary Osman Braun and Hogenberg Collection13
- Keystone View Company Lantern Slides, 1892-191213
- Proclamations, Politics, and Commerce: Broadsides from the Colonial Era to the Present at the South Caroliniana Library12
- Otto F. Ege Manuscript Collection11
- Circular Congregational Church Records, 1732-1796 (bulk 1800-1910s)10
- Isaac Rosenberg: Early Poetry and Related Documents from the Joseph Cohen Collection of World War I Literature10
- Lawrence Layden Scrapbook, 1941-194510
- The Development of the Printed Page: 150 Examples of Handpress Printing and its Antecedents, ca. 1200 to 193710
- Edmondston-Alston Family Letters and Paper Materials, 1782-19198
- Georgetown County World War II Memories8
- Gabriel Manigault Journal, 1774-17847
- James Glen Papers7
- Jewish Heritage Collection Oral Histories7
- Augusta Baker Papers, 1911-19986
- Otto F. Ege Manuscripts Collection6
- Ron Swain Map Collection6