- History of the University of South Carolina School of Medicine - Columbia6
- South Carolina Postcards6
- Ansonborough Rehabilitation Project5
- Charleston Branch of the National Association for the Advancement of Colored People Papers, 1920-19955
- Columbia Theater and Entertainment5
- Henry William Ravenel, Plants and Planter5
- Isaiah DeQuincey Newman Papers5
- Loretta Dunbar oral correspondence collection, 1974-19795
- Photographs of Cowpens National Battlefield5
- Strom Thurmond Collection, Mss 1005
- Herald-Journal Willis Collection4
- Heyward and Ferguson Family Papers, 1806-19234
- In Camp And At The Front, WW1 Selections, South Carolina Political Collections4
- Lynch Family Letters, 1858-18664
- Richland Library Archives4
- Russell Maxey Photograph Collection4
- Smith and Wells Papers, 1856-19074
- Bessie Norris Wofford collected funeral programs, 1957-19913
- C. Wayne Weart Apothecary Trade Cards, 1870-19203
- Colin J. McRae Papers, Huse Audit Series3