- Williams, Chesnut, Manning Family Papers, 1682-19263
- Anna D. Kelly Papers, 1930s - 19992
- Books and Pamphlets2
- Esau Jenkins Papers, 1963-20032
- Furman University Historical Images2
- Gussie Johnson Papers, 1940-20002
- Hunger in America2
- Oliver Hart papers, 1741-19612
- Proclamations, Politics, and Commerce: Broadsides from the Colonial Era to the Present at the South Caroliniana Library2
- Records of the Church of the Holy Cross, 1788-19422
- Thomas Benton Brooks Papers2
- YWCA of Greater Charleston, Inc., Records, 1906 - 20072
- At Low Tide Photographs1
- Augusta Baker Papers, 1911-19981
- Bratton Family Papers, 1764-1983.1
- Clariosophic Literary Society Records of University of South Carolina, 1806-19831
- Clemson University Historical Images1
- Confederate Spartanburg1
- Documentation for the People: Celebrating 125 Years as a Federal Depository Library1
- Edisto Island Historic Preservation Society Oral Histories1