- Gabriel Manigault Journal, 1774-17842
- Gertrude Sanford Legendre Papers, 1844-19962
- Greenville Civic and Commercial Journal1
- Greenville Current Campus (1958-Present)16
- Grimke family papers, 1678-19771
- Halley's Comet Project, 1985-19861
- Harry and William Birch Collection1
- Henry William Ravenel, Plants and Planter45
- Heyward and Ferguson Family Papers, 1806-19232
- Historic Southern Naturalists75
- Home Movies from Moving Image Research Collections32
- Hunger in America3
- Illustrated Newspaper Clippings, 1840-19171
- In Camp And At The Front, WW1 Selections, South Carolina Political Collections1
- Irish Heritage Oral History Collection1
- J. Arthur Brown Papers, 1937 - 19881
- James E. Campbell papers, 1930-20091
- James T. McCain Papers, 1957-19723
- Jeffersonian Americana2
- Jewish Heritage Collection Oral Histories12