- Ansonborough Rehabilitation Project1
- Architect - George E. Walker1
- At Low Tide Photographs1
- Charleston Bible Society Records, 1815-20101
- Charleston Branch of the National Association for the Advancement of Colored People Papers, 1920-19951
- Collected Papers of the Holland Family of Greenville County1
- David Wyatt Aiken Papers, 1849-19761
- Eric Crawford Oral Histories, 2007-20101
- Esau Jenkins Papers, 1963-20031
- Eugene C. Hunt Papers, 1834 - 19941
- Fairfield County Manuscript Collection1
- Flagg Family Papers, 1832-19261
- Georgetown County Memories1
- Gussie Johnson Papers, 1940-20001
- Hampstead and Bethany Cemeteries1
- Henrietta Yurchenco Field Recordings, 1970-19711
- Irish Heritage Oral History Collection1
- J. Arthur Brown Papers, 1937 - 19881
- James Glen Papers1
- Jewish Heritage Collection Oral Histories1