- President Robert C. Edwards Papers2
- Russell Maxey Photograph Collection2
- South Carolina Postcards2
- South Caroliniana Library Map Collection2
- St. Paul's Episcopal Church records, 1819-19712
- Thomas J. Tobias papers, ca. 1790-19702
- University of South Carolina Reconstruction Records2
- Views of Columbia, S.C.2
- Waring Historical Library Inaugural Theses2
- 1938 Tornado Photograph Collection1
- Armstrong Family Papers, 1900-19301
- Bessie Norris Wofford collected funeral programs, 1957-19911
- Charleston Branch of the National Association for the Advancement of Colored People Papers, 1920-19951
- Dientje Krant Kalisky Adkins Photographs, 1938-19961
- Eugene C. Hunt Papers, 1834 - 19941
- Forgotten Books1
- George LaGrange Cook Photograph Collection1
- Georgetown County Library Collection1
- Good Hope Plantation Journal, 1835-1874 (bulk 1835-1857)1
- Grimke family papers, 1678-19771