- South Carolina Historical Records Survey Collection10
- Chester County Historical Collection, 1739-19979
- Eleanor Parsons Moody Collection9
- James Glen Papers9
- Local Television Newsfilm Collections9
- Minutes of the Annual Conferences of the Baptist, Episcopal, Lutheran, Methodist, and Presbyterian Churches in South Carolina, 1785-19209
- South Carolina Aerial Photograph Indexes, 1937-19899
- Specimens from the Bob Campbell Geology Museum9
- Charles Fraser's Sketchbook, 1796-18058
- Edwin Hughes Collection7
- Phosphate, Farms, & Family: The Donner Collection7
- Russell Maxey Photograph Collection7
- William Lynch Postcard Collection7
- Barnwell Family Papers6
- Civic Services Committee Papers6
- Clemson University Historical Images6
- E.T. Start Photograph Collection6
- William A. Rosenthall Judaica Collection - Prints and Photographs6
- Belle W. Baruch Collection5
- Camperdown Mill5