- William Lynch Postcard Collection26
- The Charleston Oral History Program25
- From the Kitchen Drawer and Cupboard: The Jerred Metz Collection of Manufacturers' Recipe and Advertisement Booklets 1902-195023
- Barnwell Family Papers22
- Native American South Carolina Digital Archive22
- Sanborn Fire Insurance Maps of South Carolina21
- Bernice Robinson Papers, 1920-198919
- Georgetown County Library19
- Camilla Urso Collection18
- Gertrude Sanford Legendre Papers, 1844-199618
- South Carolina Department of Transportation County Road Maps18
- Specimens from the Bob Campbell Geology Museum17
- Survey of National Parks17
- Brookgreen Gardens Collection16
- Mills Family of Greenville16
- Georgetown County Library Collection15
- Minutes of the Annual Conferences of the Baptist, Episcopal, Lutheran, Methodist, and Presbyterian Churches in South Carolina, 1785-192015
- Henry William Ravenel Papers, 1739-193514
- South Carolina Railroad Photograph Collection14
- South Carolina LGBTQ Oral Histories, Archives, and Outreach13