- Charleston Naval Shipyard Photographs27
- Charleston Year Book, 19371
- Charleston Year Book, 19381
- Chesnut Family Papers, 1741-19001
- Chester County Historical Collection, 1739-19978
- Chibbaro Stereograph Collection: 186u-199745
- Circular Congregational Church Records, 1732-1796 (bulk 1800-1910s)23
- City Engineers's Plat Book, 1671-19516
- City Year Books for Charleston, South Carolina, 1880-19517
- City of Charleston Collection1
- Civic Services Committee Papers51
- Civil Rights Films from Moving Image Research Collections17
- Civil Rights Films from USC's Moving Image Research Collections1
- Civil War Era Maps2
- Civil War Newspaper Illustrations12
- Civil War Pamphlets138
- Clemson University Historical Images222
- Clemson's Cooperative Extension Photographs 1880-19799
- Cleveland Family Collection 3
- Cleveland L. Sellers, Jr. Papers, 1934 - 200351