Collection
- Sanborn Fire Insurance Maps of South Carolina1
- Senator Burnet R. Maybank Papers, 1914-19734
- Septima P. Clark Papers, ca. 1910-ca. 19902
- Sheet music from the Joseph M. Bruccoli Great War Collection3
- Skateboarding's Journey to the Olympics Oral History Collection2
- Slave Records in the Discrete Manuscript Collection1
- Solomon Blatt: In His Own Words2
- South Carolina Bookmobiles Collection1
- South Carolina Fall Line Collection2
- South Carolina Historical Records Survey Collection1
- South Carolina LGBTQ Oral Histories, Archives, and Outreach1
- South Carolina Postcards18
- South Carolina State Library Construction Collection2
- South Carolina and World War II3
- South Carolina and the Civil War2
- South Caroliniana Library Map Collection2
- St. Andrew's Society of Charleston Records, 1729-20011
- Standard Federal (Columbia S.C.) Photograph Collection128
- Stoney Family Papers, 1775-19491
- Strom Thurmond Collection, Mss 1003