Collection
- Simons & Lapham Architectural Drawings, 1919-19522
- Slave Records in the Discrete Manuscript Collection2
- Small-Whaley Family Papers, 1796-19941
- Smith and Wells Papers, 1856-19073
- South Carolina Fall Line Collection2
- South Carolina Historical Records Survey Collection1
- South Carolina LGBTQ Oral Histories, Archives, and Outreach1
- South Carolina Postcards1
- South Carolina Veterans Oral History Collection1
- South Caroliniana Library Map Collection5
- Specimens from the Bob Campbell Geology Museum6
- Stereographic Views of South Carolina1
- Strom Thurmond Collection, Mss 1001
- Sullivan's Island Oral History Collection3
- The American Revolution in South Carolina137
- The Charleston Oral History Program14
- The Development of the Printed Page: 150 Examples of Handpress Printing and its Antecedents, ca. 1200 to 193710
- The Joel Myerson Collection of Nineteenth-Century American Manuscripts, Images, and Ephemera218
- The Lithographs of Prentiss Taylor: a Catalogue Raisonne1
- The State Newspaper Photograph Archive2