- Cleveland L. Sellers, Jr. Papers, 1934 - 2003143
- Clubs, Organizations, and Sports9
- Cohen, Emanuel, Moses, Seixas Family Papers16
- Colin J. McRae Papers, Huse Audit Series6
- Collected Papers of the Holland Family of Greenville County7
- Collected Receipts of William Butler of Greenville7
- College of Charleston Buildings and Grounds Photograph Collection95
- College of Charleston Pamphlet Collection1
- Colleges of Greenville County9
- Color Slides from Fort Sumter National Historical Monument1
- Color slides of South Carolina State Parks423
- Columbia Fire Department1,747
- Columbia Theater and Entertainment23
- Communities - Berea3
- Communities - Five Forks18
- Communities - Travelers Rest13
- Conestee Mill4
- Congaree Photographic Prints322
- Continental Army Southern Department Records, 1778-1890 (Bulk 1778-1780)7
- Course Catalogs8